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Panadol Extra Advance Caplets - 16 Caplets

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Paracetamol 500mg boosted by 65mg caffeine — measurably stronger relief with fast-release Optizorb. 16 caplets, daytime use.

  • Paracetamol + caffeine boost.
  • Stronger than paracetamol alone.
  • Optizorb fast release.
  • Best as a daytime painkiller.
  • 16 caplets — ages 12+.
£3.59 GBP inc. VAT
In stock
Safety information 4
General sale medicine
Always read the label and patient information leaflet before use. Ask our pharmacist if you're unsure whether this product is right for you.
Contains paracetamol
Do not take with any other paracetamol-containing product. Never exceed the stated dose — overdose can cause serious liver damage.
Contains caffeine
Avoid drinking lots of coffee, tea or energy drinks while taking this product.
Pain that needs a professional
Pain persisting beyond the pack's stated limit, or with unexplained swelling, numbness, chest pain or following a serious injury, should be assessed rather than self-treated.

Product overview

About Panadol Extra Advance

Paracetamol with its proven sidekick: 500mg paracetamol plus 65mg caffeine per caplet — a combination shown to deliver measurably stronger pain relief than paracetamol alone — with Optizorb for faster release. For the headaches ordinary tablets don't quite reach. 16 caplets.

What caffeine adds pharmacologically

Caffeine isn't in there to wake you up — it genuinely potentiates paracetamol, effectively getting more relief from the same dose. The corollary: treat it as a daytime painkiller, and don't stack it on top of an espresso habit.

How to take

Adults and children 12+: per pack limits, spaced at least 4 hours. Nothing else containing paracetamol alongside — the rule has no exceptions.

Good to know

Frequent headaches that keep needing stronger relief are a pattern worth breaking — medication-overuse headache is real, and caffeine combinations are a known route into it. A GP conversation beats escalation.

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