More From The Nytol Range

Nytol One a Night 50mg - 20 Tablets

One 50mg diphenhydramine tablet before bed — clinically proven help falling asleep during a bad patch. Pharmacist-checked. 20 tablets.

  • Full-strength 50mg single dose.
  • Clinically proven sleep aid.
  • One tablet, 20 minutes before bed.
  • 20-night supply.
  • Limit: 1 pack per order.
Regular price £6.89 GBP inc. VAT
In stock
Safety information 3
Pharmacy medicine — pharmacist review
You'll answer a short set of questions before this can be added to your basket, and our pharmacist reviews every order before it is dispatched.
Causes drowsiness
This medicine makes most people sleepy. Do not drive, cycle or use tools or machines until you know how it affects you, and avoid alcohol.
See a pharmacist or GP if it persists
If symptoms don't improve within a few days, get worse, or keep coming back, stop self-treating and get advice from a pharmacist or your GP.

Product overview

About Nytol One-A-Night

The full-strength Nytol: a single 50mg diphenhydramine tablet before bed, clinically proven to shorten the time it takes to fall asleep. One tablet, one night — 20 easy-swallow tablets for temporary sleeplessness.

How it works

Diphenhydramine is a sedating antihistamine: it dials down the brain's wakefulness signal, easing you towards sleep rather than knocking you out. The 50mg one-tablet dose replaces the two-tablet routine of standard Nytol.

How to take

Adults: one tablet about 20 minutes before bed. Leave yourself a full night — short nights invite morning drowsiness. Short-term use only; if sleep hasn't reset within two weeks, talk to a pharmacist or GP.

Good to know

Tolerance builds within days if used nightly, which is why it's a circuit-breaker for a bad patch, not a routine. No alcohol alongside, and skip it entirely if you might need to drive before it wears off.

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