Nytol One a Night 50mg - 20 Tablets
One 50mg diphenhydramine tablet before bed — clinically proven help falling asleep during a bad patch. Pharmacist-checked. 20 tablets.
- Full-strength 50mg single dose.
- Clinically proven sleep aid.
- One tablet, 20 minutes before bed.
- 20-night supply.
- Limit: 1 pack per order.
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Pharmacy medicine — pharmacist review
Causes drowsiness
See a pharmacist or GP if it persists
Product overview
About Nytol One-A-Night
The full-strength Nytol: a single 50mg diphenhydramine tablet before bed, clinically proven to shorten the time it takes to fall asleep. One tablet, one night — 20 easy-swallow tablets for temporary sleeplessness.
How it works
Diphenhydramine is a sedating antihistamine: it dials down the brain's wakefulness signal, easing you towards sleep rather than knocking you out. The 50mg one-tablet dose replaces the two-tablet routine of standard Nytol.
How to take
Adults: one tablet about 20 minutes before bed. Leave yourself a full night — short nights invite morning drowsiness. Short-term use only; if sleep hasn't reset within two weeks, talk to a pharmacist or GP.
Good to know
Tolerance builds within days if used nightly, which is why it's a circuit-breaker for a bad patch, not a routine. No alcohol alongside, and skip it entirely if you might need to drive before it wears off.
Product details
- Active ingredients Diphenhydramine hydrochloride 50mg
- Vendor Nytol
- SKU 3824620
Important information
Please read before purchase. The information provided regarding medicines, dietary supplements or ointments is not to be taken as medical advice.
Consult a healthcare professional prior to use if you are pregnant, nursing, taking medication, or have a medical condition.
Keep out of reach of children. Store in a cool, dry place. Do not use if the seal under the cap is broken or missing. Always read the label and any patient information leaflet before use.
Frequently asked questions
Nytol One-A-Night or Original 25mg?
Same active, different arithmetic: One-A-Night is a single 50mg tablet, Original is 25mg taken as two. One-A-Night suits people who prefer one tablet.
Will I feel groggy tomorrow?
Some people do, especially on short nights. Take it only when you can sleep 7–8 hours, and see how it affects you before driving.
Can I take it every night?
No — tolerance builds quickly and it stops working. It's for breaking a short bad spell; persistent insomnia deserves a GP conversation.
Shipping information
We deliver across mainland UK by Royal Mail Tracked, usually within 3–5 working days.
Delivery is £2.99, or free on orders over £40. You'll get tracking by email once your order is on its way.
For full details, see our Delivery Policy.